Protective Effect of Curcumin Longa on Sodium Arsenite Induced Toxicity in Swiss Albino Mice

Authors

  • Dr. Pramod Shanker  TGT (SCIENCE), S.R.P.S.Govt.SR.SEC.School, Gardanibagh, Patna, India

Keywords:

Sodium Arsenite, Curcumin Longa, Protective Effect, Swiss Albinomice

Abstract

Arsenic in the present times has caused serious health hazards in the human population. In India, the arsenic poisoning in ground water in Gangetic plains has increased many folds. The exposed population are suffering from various arsenicosis symptoms such as hyperkeratosis, melanosis, and other internal organ diseases of gastrointestinal, cardiovascular, hormonal and others. Hence, the present study is focused to combat the deleterious effect of arsenic toxicity in animal models utilizing medicinal plant extract. The animals (Swiss albino mice) were treated with Sodium arsenite at the dose of 8 mg per kg body weight for 16 weeks to make arsenic model and upon these arsenic pre-treated rats rhizome extract of Curcuma longa at the dose of 25 mg per kg body weight was administered for 4 weeks to study the ameliorative effects of this plant extract. After the entire treatment, rats were sacrificed and their blood samples were obtained and analysed for haematological and biochemical study. The study shows that arsenic induced toxicity caused deleterious effect on the mice at the haematological and biochemical levels and there was significant normalisation in the animal at all the respective levels. Hence, Curcumin longa possesses ameliorative properties against arsenic induced toxicity and can be used for human purpose after dose titration.

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International Journal of Scientific Research in Science and Technology

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2018-03-30

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Volume 4, Issue 7, March-April-2018

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[1]
Dr. Pramod Shanker, " Protective Effect of Curcumin Longa on Sodium Arsenite Induced Toxicity in Swiss Albino Mice, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 4, Issue 7, pp.1030-1039, March-April-2018.